11 edition of Drug Transporters found in the catalog.
August 24, 2007
Written in English
|Contributions||Guofeng You (Editor), Marilyn E. Morris (Editor), Binghe Wang (Series Editor)|
|The Physical Object|
|Number of Pages||889|
This new edition overviews drug transporters and presents theprinciples of drug transport and associated techniques, featuringnew chapters on multidrug and toxin extrusion proteins, placentaltransport, in silico approaches in drug discovery, andregulatory guidance for drug transport studies in drugdevelopment. The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene allmusictrends.com is represented in all extant phyla, from prokaryotes to humans.. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA allmusictrends.comro: IPR
Aug 26, · From the book: Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development Chapter 4 Drug Transporters in the Kidney. Git Weng Chung, Sarah Faye Billington, Sarah Elizabeth Jenkinson and Colin Douglas Brown With a high expression of both uptake and efflux transporters, together with metabolic enzymes, the proximal tubule in Author: Git Weng Chung, Sarah Faye Billington, Sarah Elizabeth Jenkinson, Colin Douglas Brown. The SLC superfamily includes genes that encode facilitated transporters and ion-coupled secondary active transporters. Forty-eight SLC families with ~ transporters have been identified in the human genome. Many SLC transporters serve as drug targets or in drug absorption and disposition.
May 04, · Drug transporters 1. Drug Transporters - Dr. Chandini Rao Moderator: Dr. Padmaja Udaykumar 2. Overview • Introduction • Basic transport mechanisms • Membrane transporters – ABC & SLC superfamilies • Regulation of transporter expression • Transporters involved in Pharmacokinetics - Hepatic transporters - Renal transporters • Transporters involved in Pharmacodynamics • Membrane. There is a small subset of transporters that move substrates in the opposite direction and are classified as influx transporters. Collectively, drug transporters contribute to the pharmacokinetic.
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Aug 08, · • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for.
Mar 24, · Transporters are widely expressed in various human tissues and are routinely evaluated during the process of drug development and approval. Over the past decade, increasing evidence shows that drug transporters are important in both normal physiology and allmusictrends.com by: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects.
This book will give an overview on the transporter families which are. Mar 02, · Retaining the same basic format as its predecessor, the second edition of Drug Transporters: Molecular Characterization and Role in Drug Disposition provides an overview of drug transporters and presents the principles of drug transport and associated techniques.
Several new chapters are added and others are thoroughly updated or expanded.5/5(2). There are two major superfamilies of transporters important in drug disposition: solute carrier (SLC) transporters, a family of passive and active transporters that rely on chemical and/or electrical gradients for transport, and ATP-binding cassette (ABC) transporters, a family of primary active transporters that are ATP dependent.
A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition.
Although the human genome encodes many membrane transporters, relatively few (~ 20) are drug transporters involved in the disposition of drugs. Modern drug discovery and development is experiencing a major paradigm shift in using chemicals that are hydrophilic and polar, resulting in the selection of poorly permeable compounds.
Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in.
As a pioneer in the drug transporter field for 20 years, SOLVO is dedicated to exploring the science of transporters and their role in xenobiotic efficacy and safety. Anniversary Conference Budapest Download it once and read it on your Kindle device, PC, phones or tablets.
Use features like bookmarks, note taking and highlighting while reading Drug Transporters: Molecular Characterization and Role in Drug Disposition (Wiley Series in Drug Discovery and Development Book 20).5/5(2).
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects.
This book will give an overview on the transporter families which are most important for drug therapy. This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field.
Transporters are known determinants of drug disposition and efficacy/toxicity. Nov 19, · It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects.
This book will give an overview on the transporter families which are most important for drug allmusictrends.com: Springer Berlin Heidelberg.
The multidrug resistance (MDR) phenotype mediated by drug efflux transporters such as P-glycoprotein has long been recognized as one of these key chemoresistance mechanisms. MDR may be intrinsic or acquired in response to chemotherapy. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology.
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy.
In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed.
Quantity. Add to cart. Gerhard Ecker is Full Professor for Pharmacoinformatics at the Department of Pharmaceutical Chemistry, University of Vienna (Austria). His main scientific interests are pharmacoinformatic approaches to target drug transporters, in silico screening methods for promiscuous targets and antitargets, and new approaches for data integration and data mining.
Jul 01, · Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers.
This new edition goes beyond LC-MS and features all-new chapters on how to evaluate Book Edition: 2. from book Handbook of Drug-Nutrient Interactions / Ed.
de J.I. Boullata, • Highlight the importance of drug transporters to clinically observed drug–drug interactions, drug–nutrient. 21 April - 22 April 3rd SCI-RSC Symposium on Transporters in Drug Discovery and Development.
Organised by: SCI's Fine Chemicals Group, RSC’s Biological and Medicinal Chemistry Sector and the Drug Metabolism Discussion Group (DMDG). London, UK. Read "Drug Transporters Molecular Characterization and Role in Drug Disposition" by Binghe Wang available from Rakuten Kobo.
This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, fe Brand: Wiley.Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).
Ishikawa T(1), Onishi Y, Hirano H, Oosumi K, Nagakura M, Tarui allmusictrends.com by: Together with OAT1, OAT3 and URAT1, OAT2 was shown to be expressed in both ductal and serous acinar cells of salivary glands, where it may play a role in the transport of organic anions and uric acid .
As one of the main transporters responsible for ocular homeostasis and drug disposition, OAT2 is also expressed in the corneal epithelium .